Synthesis and characterization of silver nanoparticles using <i>Origanum onites</i> leaves: Cytotoxic, apoptotic, and necrotic effects on Capan-1, L929, and Caco-2 cell lines

Abstract In this study, Origanum onites was used to synthesize the silver nanoparticles (AgNPs@Org). The structure of identified by spectroscopic techniques. maximum absorption determined as 433 nm UV-Vis spectroscopy. Fourier-transform infrared spectroscopy spectrum, characteristic signal observed at 3,262 cm −1 belonging OH group. crystal revealed X-ray diffraction analysis. peaks (2 θ ) can be indexed 111, 200, 220, 311, and 222 components representing face-centered cubic unit structure. spherical particle size calculated 18.1 transmission electron microscopy. Cytotoxic effects extract AgNPs@Org were executed MTT assay using Capan-1, L929, Caco-2 cell lines. exhibited excellent cytotoxic effect on Capan-1 lines with viability 37.6% (0.5 µg·mL ). However, O. found 24.6% 55.4% 1.0 0.5 , respectively. 31.7% (1.0 L929 lines, noticeable lethal influence not detected for nanoparticles. other words, did act a